Continuous-flow stereoselective reduction of prochiral ketones in a whole cell bioreactor with natural deep eutectic solvents
نویسندگان
چکیده
Immobilized whole cells of Rhodotorula rubra MIM147 were used in a packed bed flow reactor for the enantioselective reduction ?-ketonitriles and obtainment key building block synthesis antidepressant drug duloxetine.
منابع مشابه
Towards the development of continuous, organocatalytic, and stereoselective reactions in deep eutectic solvents
Different deep eutectic solvent (DES) mixtures were studied as reaction media for the continuous synthesis of enantiomerically enriched products by testing different experimental set-ups. L-Proline-catalysed cross-aldol reactions were efficiently performed in continuo, with high yield (99%), anti-stereoselectivity, and enantioselectivity (up to 97% ee). Moreover, using two different DES mixture...
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ژورنال
عنوان ژورنال: Green Chemistry
سال: 2022
ISSN: ['1463-9262', '1463-9270']
DOI: https://doi.org/10.1039/d1gc03786b